it wont work, if you downloaded the duplex release you need to extract again those files and patch it again, seems like you had a problem patching before, i had the same problem, just try again with clean, untouched files specially the 2 gb file
btw you need to execute the patcher in a dir where you placed the game lets say c:/uncharted/BLUS-BLES**** well you need to copy the patcher files to the uncharted dir and then run the patcher
cheers