Info -
If want to use CodeUnique, I strongly suggest that you stay on 3.55 CFW. I don't plan to go to Rogero 4.21 CFW at the moment. Unless there is a way to downgrade to 3.55 easily. I saw a post that a user have manage to downgrade to 3.55 by using the special downgreader pup. Waiting for more confirmation.
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MajorDisaster
I think, CodeUnique can be resign with 4.21 keys. I believe oct0xor might release a update soon.
Maybe. If the Eboot values are not change except for the keys, the cheats might work.
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SkillerCMP
might provide some information.