RE6 has been known to have issues copying over via FTP from a Computer to the internal hard drive because the game has about 19,000 little files, and sometimes FTP upload of this game doesnt copy over all files. I had to put the game onto a USB Flash drive and then plug that into the USB port of my PS3 and then used Multiman to copy it onto my PS3 internal HDD and then I had no more issues.
PS3 Slim Rogero CFW 4.40 v1.03 (500GB internal HDD)
Sony Bravia 1080p HDTV. iMac 10.8.2. Popcorn Hour A-300